反应详情

A solution of 32 mg (0.043 mmol) of tert-butyl [2-[[(S)-2-[[(S)-1-[[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]carbamoyl]-2-imidazol-4-ylethyl]carbamoyl]-3-phenylpropyl]sulphonyl]-2-methylpropyl]carbamate in 2 ml of dioxan is treated with 2 ml (4 mmol) of 2N hydrochloric acid in dioxan while cooling with ice and stirred for 1 hour. Subsequently, the solution is lyophilized and there are obtained 30 mg of (S)-α-[(S)-α-[[[(2-amino-1,1-dimethylethyl)sulphonyl]methyl]hydrocinnamamido]-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]imidazole-4-propionamide dihydrochloride as a colourless powder; MS: 646 (M+H)+.

1. temperaturewhile cooling with ice