Water → HCID 178476516, compound

Participants

Reaction Steps

A mixture of 300 mg (0.38 mmol) of benzyl [2-[[(S)-2-[[(S)-1-[[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]carbamoyl]-2-imidazol-4-ylethyl]carbamoyl]-3-phenylpropyl]sulphonyl]-1,1-dimethylethyl]carbamate and 30 mg of palladium/carbon (10%) in 8 ml of acetic acid is hydrogenated at room temperature for 3 hours. Thereafter, the catalyst is filtered off, the reaction solution is evaporated and the residue obtained is lyophilized from water. There are obtained 240 mg of (S)-α-[(S)-α-[[(2-amino-2-methylpropyl)sulphonyl]methyl]hydrocinnamamido]-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]imidazole-4-propionamide diacetate as a colourless, amorphous powder; MS: 646 (M+H)+.

Provenance & Evidence