2-((tert-Butoxycarbonyl)amino)-3-(thiazol-4-yl)propanoic acid → tert-butyl [(RS)-1-[[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]carbamoyl]-2-(4-thiazolyl)ethyl]carbamate

Participants

Reaction Steps

In a manner analogous to the procedure described in Example 16(c), by condensing (RS)-Boc-3-(4-thiazolyl)alanine, prepared according to the synthesis described in EPA 0274259, and 3-amino-4-cyclohexyl-1-cyclopropyl-1,2-butanediol there is obtained tert-butyl [(RS)-1-[[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]carbamoyl]-2-(4-thiazolyl)ethyl]carbamate (1:1 epimer mixture) as a colourless solid; MS: 482 (M+H)+.

Provenance & Evidence