HCID 178431645, compound → HCID 178455619, compound

Participants

Reaction Steps

A solution of 90 mg (0.3 mmol) of (S)-α-[(S)-α-[(tert-butylsulphonyl)methyl]hydrocinnamamido]-N-[(S)-1-[(4R,5S)-5-cyclopropyl-2,2-dimethyl-1,3-dioxolan-4-yl]-2-(4-oxocyclohexyl)ethyl]imidazole-4-propionamide in 1 ml of methanol and 1 ml of 2N hydrochloric acid is stirred at room temperature for 3 hours. Subsequently, the reaction solution is evaporated and, for purification, the residue is chromatographed on 20 g of silica gel using a 14:1:0.1 mixture of methylene chloride, methanol and ammonia as the eluent. There are obtained 13 mg of (S)-α-[(S)-α-[(tert-butylsulphonyl)methyl]hydrocinnamamido]-N-[(1S,2R,3S)-3-cyclopropyl-2,3-dihydroxy-1-[(4-oxocyclohexyl)methyl]propyl]imidazole-4-propionamide as a colourless solid; MS: 684 (M+H)+.

Provenance & Evidence