Diethyl [(thiophen-3-yl)methyl]propanedioate → HCID 67723767, compound

Participants

Reaction Steps

This compound was prepared analogously to Example 1 by the enzymatic hydrolysis of ethyl (RS)-α-[(tert-butylsulphonyl)methyl]-3-thiophenepropionate which, in turn, was prepared starting from diethyl 3-thienylmethylmalonate [J. Am. Chem. Soc. 76, 4466 (1954)] analogously to the synthesis of ethyl (RS)-α-[(tert-butylsulphonyl)methyl]hydrocinnamate described in EPA 0236734, MS: 318 (M)+.

Provenance & Evidence