HRID2294760

反应详情

EQUATION

反应方程式

HRID 2294760 的结构方程式

AUXILIARIES

试剂、催化剂与溶剂

1

PROCEDURE

实验过程

Under cooling with ice, ethylene glycol (434 mg) was dissolved into acetone (20 ml), and pyridine (632 mg) was added thereto and then lauroyl chloride (1532 mg) was added dropwise thereto. The temperature of the solution was warmed to room temperature, and it was stirred for 2 hours. The mixture was evaporated. To the residue was added water, and the solution was extracted with ethyl acetate. The organic layer was washed with water (three times), dried over magnesium sulfate and evaporated. The residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=4:1) to give the title compound (1.63 g) having the following physical data.

WORKUP

后处理

  1. additionwas added
  2. customThe mixture was evaporated
  3. additionTo the residue was added water
  4. extractionthe solution was extracted with ethyl acetate
  5. washThe organic layer was washed with water (three times)
  6. dry with materialdried over magnesium sulfate
  7. customevaporated
  8. customThe residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=4:1)