2-Methoxyethanol → 2-Methoxyethyl 5-amino-4-oxopentanoate--hydrogen chloride (1/1)

HRID 229477Notes

Reaction equation

[CH3:1][O:2][CH2:3][CH2:4]O.[ClH:6].[NH2:7][CH2:8][C:9](=[O:15])[CH2:10][CH2:11][C:12]([OH:14])=[O:13]>>[ClH:6].[NH2:7][CH2:8][C:9](=[O:15])[CH2:10][CH2:11][C:12]([O:14][CH2:4][CH2:3][O:2][CH3:1])=[O:13]

Participants

Reactant 2

HCID 80192-Methoxyethanol

HCID 123608Aminolevulinic Acid Hydrochloride

Product 1

HCID 426018902-Methoxyethyl 5-amino-4-oxopentanoate--hydrogen chloride (1/1)

Procedure

From 2-methoxyethanol (5.0 g; 66 mmol) and 5-amino-4-oxopentanoic acid hydrochloride (1.0 g; 6.0 mmol) at 70° C. The reaction was complete after 1 h. The yield was 1.25 g (93%) of yellowish oil.

Workup

customat 70° C

Sources & evidence

ORD record: ord-a3bac752c5d743049d409df48573e45e
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07563819B1

Reaction notes

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