Potassium Hydroxide → HCID 21471076, compound

HRID 2294770Notes

Reaction equation

HRID 2294770 reaction equation
[OH-].[K+].[Cl:3][C:4]1[CH:5]=[C:6]([CH:24]=[CH:25][CH:26]=1)[C:7]([NH:9][C:10]([C:17]1[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=1)([CH3:16])[C:11]([O:13]CC)=[O:12])=[O:8]>C(O)C.O>[Cl:3][C:4]1[CH:5]=[C:6]([CH:24]=[CH:25][CH:26]=1)[C:7]([NH:9][C:10]([C:17]1[CH:18]=[CH:19][C:20]([CH3:23])=[CH:21][CH:22]=1)([CH3:16])[C:11]([OH:13])=[O:12])=[O:8]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 21471075Ethyl 2-(m-chlorobenzamido)-2-(p-tolyl)propionate

Product 1

HCID 21471076HCID 21471076, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

1.2 g (0.02M) of potassium hydroxide was dissolved in a mixed solution of 30 ml of ethanol and 5 ml of H2O. To this solution, 3.5 g (0.01M) of ethyl 2-(m-chlorobenzamido)-2-(p-tolyl)propionate obtained in Example I was added. The resulting solution was heated for 1 hr with reflux, cooled and distilled in vacuo to remove ethanol. The remainder was adjusted into pH 2 with 2 N HCl solution and extracted with methylene dichloride. Thereafter, the extract was distilled in vacuo, to give 2.9 g of the titled compound: 92 % Yield.

Workup

  1. temperatureThe resulting solution was heated for 1 hr
  2. temperaturewith reflux
  3. temperaturecooled
  4. distillationdistilled in vacuo
  5. customto remove ethanol
  6. extractionextracted with methylene dichloride
  7. distillationThereafter, the extract was distilled in vacuo

Sources & evidence

ORD record
ord-7718bfba25a24c83ba4c7b94d8555a85
Source dataset
uspto-grants-1997_11
Patent number
US05691278

Reaction notes

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