R-56109 hydrochloride → HCID 21471894, compound

HRID 2294817Notes

Reaction equation

HRID 2294817 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][C:7]2[C:10]([C:14](=[O:19])[CH2:15][CH2:16][CH2:17]Cl)=[C:11]([CH3:13])[S:12][C:6]=2[CH2:5]1)(=[O:3])[CH3:2].Cl.[F:21][C:22]1[CH:36]=[CH:35][C:25]2[C:26]([CH:29]3[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]3)=[N:27][O:28][C:24]=2[CH:23]=1>>[C:1]([N:4]1[CH2:9][CH2:8][C:7]2[C:10]([C:14](=[O:19])[CH2:15][CH2:16][CH2:17][N:32]3[CH2:31][CH2:30][CH:29]([C:26]4[C:25]5[CH:35]=[CH:36][C:22]([F:21])=[CH:23][C:24]=5[O:28][N:27]=4)[CH2:34][CH2:33]3)=[C:11]([CH3:13])[S:12][C:6]=2[CH2:5]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 11334359R-56109 hydrochlorideHCID 21471908HCID 21471908, compound

Product 1

HCID 21471894HCID 21471894, compoundYield 62%

Procedure

The reaction and procedure were conducted in a similar manner as in Example 24 using 1.4 g of 6-acetyl-3-(4-chlorobutyryl)-4,5,6,7-tetrahydro-2-methylthieno[2,3-c]pyridine and 1.3 g of 4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride to give 1.4 g of 6-acetyl-3-(4-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)butyryl)-4,5,6,7-tetrahydro-2-methylthieno[2,3-c]pyridine as an oil.

Workup

  1. customThe reaction and procedure

Sources & evidence

ORD record
ord-97a6ad067f00429e916a541619823a7c
Source dataset
uspto-grants-1997_11
Patent number
US05691330

Reaction notes

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