Oxalate → HCID 21471794, compound

HRID 2294820Notes

Reaction equation

HRID 2294820 reaction equation
[C:1]([CH:4]1[NH:9][CH2:8][C:7]2[S:10][C:11]([CH2:13][CH2:14]Br)=[CH:12][C:6]=2[CH2:5]1)(=[O:3])[CH3:2].Cl.[F:17][C:18]1[CH:32]=[CH:31][C:21]2[C:22]([CH:25]3[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]3)=[N:23][O:24][C:20]=2[CH:19]=1.C([O-])(=O)C([O-])=O>>[C:1]([CH:4]1[NH:9][CH2:8][C:7]2[S:10][C:11]([CH2:13][CH2:14][N:28]3[CH2:27][CH2:26][CH:25]([C:22]4[C:21]5[CH:31]=[CH:32][C:18]([F:17])=[CH:19][C:20]=5[O:24][N:23]=4)[CH2:30][CH2:29]3)=[CH:12][C:6]=2[CH2:5]1)(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 71081OxalateHCID 11334359R-56109 hydrochlorideHCID 21471980HCID 21471980, compound

Product 1

HCID 21471794HCID 21471794, compoundYield 68.9%

Procedure

The reaction and procedure were conducted in a similar manner as in Example 24 using 0.7 g of 5-acetyl-2-(2-bromoethyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine and 0.61 g of 4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride to give 0.7 g of 5-acetyl-2-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)ethyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine as an oil, m.p. 170°-172° C. as oxalate thereof.

Workup

  1. customThe reaction and procedure

Sources & evidence

ORD record
ord-db7e6904f8a04329a1d641d4193b9982
Source dataset
uspto-grants-1997_11
Patent number
US05691330

Reaction notes

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