R-56109 hydrochloride → HCID 21471873, compound

HRID 2294822Notes

Reaction equation

HRID 2294822 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][C:7]2[C:10]([C:14](=[O:17])[CH2:15]Cl)=[C:11]([CH3:13])[S:12][C:6]=2[CH2:5]1)(=[O:3])[CH3:2].Cl.[F:19][C:20]1[CH:34]=[CH:33][C:23]2[C:24]([CH:27]3[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]3)=[N:25][O:26][C:22]=2[CH:21]=1>>[C:1]([N:4]1[CH2:9][CH2:8][C:7]2[C:10]([C:14](=[O:17])[CH2:15][N:30]3[CH2:29][CH2:28][CH:27]([C:24]4[C:23]5[CH:33]=[CH:34][C:20]([F:19])=[CH:21][C:22]=5[O:26][N:25]=4)[CH2:32][CH2:31]3)=[C:11]([CH3:13])[S:12][C:6]=2[CH2:5]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 11334359R-56109 hydrochlorideHCID 21471952HCID 21471952, compound

Product 1

HCID 21471873HCID 21471873, compoundYield 53.7%

Procedure

The reaction and procedure were conducted in a similar manner as in Example 24 using 1.0 g of 6-acetyl-3-chloroacetyl-4,5,6,7-tetrahydro-2-methylthieno[2,3-c]pyridine and 0.95 g of 4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride to give 0.9 g of 6-acetyl-3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)-1-oxoethyl)-4,5,6,7-tetrahydro-2-methylthieno[2,3-c]pyridine as an oil, m.p. 92°-94° C. as 3/2oxalate 1/2hydrate thereof.

Workup

  1. customThe reaction and procedure

Sources & evidence

ORD record
ord-8f13fec62e8448e7a44073fad070ae5a
Source dataset
uspto-grants-1997_11
Patent number
US05691330

Reaction notes

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