Oxalate → HCID 21472083, compound

HRID 2294823Notes

Reaction equation

[C:1]([N:4]1[CH2:9][CH2:8][C:7]2[C:10]([CH2:16][CH2:17]Cl)=[C:11]([CH2:13][CH2:14][CH3:15])[S:12][C:6]=2[CH2:5]1)(=[O:3])[CH3:2].Cl.[F:20][C:21]1[CH:35]=[CH:34][C:24]2[C:25]([CH:28]3[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]3)=[N:26][O:27][C:23]=2[CH:22]=1.C([O-])(=O)C([O-])=O>>[C:1]([N:4]1[CH2:9][CH2:8][C:7]2[C:10]([CH2:16][CH2:17][N:31]3[CH2:30][CH2:29][CH:28]([C:25]4[C:24]5[CH:34]=[CH:35][C:21]([F:20])=[CH:22][C:23]=5[O:27][N:26]=4)[CH2:33][CH2:32]3)=[C:11]([CH2:13][CH2:14][CH3:15])[S:12][C:6]=2[CH2:5]1)(=[O:3])[CH3:2]

Participants

Reactant 3

HCID 71081Oxalate

HCID 11334359R-56109 hydrochloride

HCID 21471888HCID 21471888, compound

Product 1

HCID 21472083HCID 21472083, compoundYield 38.3%

Procedure

The reaction and procedure were conducted in a similar manner as in Example 24 using 1.7 g of 6-acetyl-3-(2-chloroethyl)-4,5,6,7-tetrahydro-2-propylthieno[2,3-c]pyridine and 1.0 g of 4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride to give 0.7 g of 6-acetyl-2-propyl-3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)ethyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine as an oil, m.p. 178°-180° C. (decomposition) as oxalate 1/2hydrate thereof.

Workup

customThe reaction and procedure

Sources & evidence

ORD record: ord-c5b0cb9203e2429290d96d739b64d1b4
Source dataset: uspto-grants-1997_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05691330

Reaction notes

Loading…