R-56109 hydrochloride → HCID 21472035, compound

HRID 2294856Notes

Reaction equation

HRID 2294856 reaction equation
Cl[CH2:2][CH2:3][CH2:4][C:5]([C:7]1[S:16][C:15]2[CH2:14][CH2:13][CH2:12][NH:11][C:10](=[O:17])[C:9]=2[CH:8]=1)=[O:6].Cl.[F:19][C:20]1[CH:34]=[CH:33][C:23]2[C:24]([CH:27]3[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]3)=[N:25][O:26][C:22]=2[CH:21]=1>>[F:19][C:20]1[CH:34]=[CH:33][C:23]2[C:24]([CH:27]3[CH2:28][CH2:29][N:30]([CH2:2][CH2:3][CH2:4][C:5]([C:7]4[S:16][C:15]5[CH2:14][CH2:13][CH2:12][NH:11][C:10](=[O:17])[C:9]=5[CH:8]=4)=[O:6])[CH2:31][CH2:32]3)=[N:25][O:26][C:22]=2[CH:21]=1

Participants

3

Reactant 2

HCID 11334359R-56109 hydrochlorideHCID 21472038HCID 21472038, compound

Product 1

HCID 21472035HCID 21472035, compoundYield 11.8%

Procedure

The reaction and procedure were conducted in a similar manner as in Example 24 using 1.1 g of 2-(4-chlorobutyryl)-5,6,7,8-tetrahydro-4H-thieno[3,2-c]azepin-4-one and 1.0 g of 4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride to give 0.21 g of 2-(4-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)butyryl)-5,6,7,8-tetrahydro-4H-thieno[3,2-c]azepin-4-one, m.p. 142°-143° C.

Workup

  1. customThe reaction and procedure

Sources & evidence

ORD record
ord-d4e7d56fe67d417bb70cc79e81f90e79
Source dataset
uspto-grants-1997_11
Patent number
US05691330

Reaction notes

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