1-Benzylpiperazine → HCID 21472242, compound

HRID 2294885Notes

Reaction equation

HRID 2294885 reaction equation
[F:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH:6]([C:12]([N:14]1[CH2:19][CH2:18][N:17]([CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:16][CH2:15]1)=O)[O:7]2.FC1C=CC=C2C=1CCC(C(O)=O)O2.C(N1CCNCC1)C1C=CC=CC=1>>[F:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH:6]([CH2:12][N:14]1[CH2:15][CH2:16][N:17]([CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:18][CH2:19]1)[O:7]2

Participants

4

Reactant 3

HCID 759941-BenzylpiperazineHCID 214722125-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acidHCID 22911299HCID 22911299, compound

Product 1

HCID 21472242HCID 21472242, compound

Procedure

By carrying out the preparation as in Example 1, but using, at the start, 1-[(5-fluorochroman-2-yl) carbonyl]-4-benzylpiperazine resulting from the condensation of 5-fluorochroman-2-carboxylic acid with N-benzylpiperazine, the title compound is obtained.

Workup

  1. customthe preparation as in Example 1

Sources & evidence

ORD record
ord-b8b22dba63ee4eacacdbc1b93d9b1346
Source dataset
uspto-grants-1997_11
Patent number
US05691340

Reaction notes

Loading…