HCID 21472367, compound → HCID 21472358, compound

Participants

Reaction Steps

0.7 g (1.1 mmole) of the compound obtained in step 9 was dissolved in 5 ml of toluene and to the resulting solution were added 486 mg (1.32 mmole) of 2-(tributyltin)-pyridine and 25 mg (0.022 mmole) of Pd(PPh3)4. The resultant was heated to reflux for 16 hours under argon gas, cooled and extracted with a mixture of ethyl acetate and water. The organic layer was dried over MgSO4 and concentrated under reduced pressure. The residue was purified with column chromatography (ethyl acetate) to obtain 389 mg of the title compound (yield 56%).

Provenance & Evidence