Bromine → HCID 178441431, compound

Participants

Reaction Steps

0.69 g (2.45 mmole) of the compound obtained in step 7 of Example 1 was dissolved in 10 ml of MeOH--H2O (9:1) and to the resulting solution was added 4.12 g (49 mmole) of NaHCO3. The resultant was stirred until NaHCO3 was dissolved and thereto was added 2.0 ml (4.9 mmole) of Br2. The resulting solution was stirred for 1 hour at room temperature and extracted with a mixture of water and ethyl acetate. The organic layer was dried over MgSO4 and evaporated under reduced pressure to obtain 0.75 g of the title compound (quantitative).

Provenance & Evidence