Acetic Acid → 4-[(2-Butyl pyrazolo(1,5-a) pyridin-3-yl) carbonyl]benzoic acid

HRID 2294904Notes

Reaction equation

HRID 2294904 reaction equation
[CH2:1]([C:5]1[C:13]([C:14]([C:16]2[CH:23]=[CH:22]C(C#N)=[CH:18][CH:17]=2)=[O:15])=[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][N:7]2[N:6]=1)[CH2:2][CH2:3][CH3:4].S(=O)(=O)(O)O.[C:29]([OH:32])(=[O:31])[CH3:30]>O>[CH2:1]([C:5]1[C:13]([C:14]([C:16]2[CH:23]=[CH:22][C:30]([C:29]([OH:32])=[O:31])=[CH:18][CH:17]=2)=[O:15])=[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][N:7]2[N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 21472341HCID 21472341, compound

Product 1

HCID 214723324-[(2-Butyl pyrazolo(1,5-a) pyridin-3-yl) carbonyl]benzoic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A mixture of 845 mg of the product of Example 2 and 15 ml of a mixture in equal proportions of sulfuric acid, acetic acid and water was refluxed for 2 hours and the mixture was cooled down, taken up in water, filtered, washed with water and dried at 80° C. under reduced pressure.

Workup

  1. temperaturewas refluxed for 2 hours
  2. temperaturethe mixture was cooled down
  3. filtrationfiltered
  4. washwashed with water
  5. customdried at 80° C. under reduced pressure

Sources & evidence

ORD record
ord-fd3cc4fd69d44a7b8665948fd8dce526
Source dataset
uspto-grants-1997_11
Patent number
US05691347

Reaction notes

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