HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → Lithium 2-methyl-2-(5-pyrimidinyl)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Ethyl 2-methyl-2-(5-pyrimidinyl)propionate | HCID 21471571 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Lithium 2-methyl-2-(5-pyrimidinyl)propionate | HCID 23708609 | — |
Reaction Steps
A mixture of ethyl 2-methyl-2-(5-pyrimidinyl)propionate (4.64 g), 1.0N lithium hydroxide (26 mL) and THF (100 mL) was heated to reflux under argon for 26 h. The mixture was allowed to cool, adjusted to pH 7 with acetic acid, and concentrated to dryness to give 4.11 g of lithium 2-methyl-2-(5-pyrimidinyl)propionate as a pale solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05691323 |
| Source dataset | uspto-grants-1997_11 |
| ORD ID | ord-f05915991b0345408594eb1106f8a1bf |
| Source note | uspto-grants-1997_11 |