Triethylamine → HCID 21472505, compound

Participants

Reaction Conditions

Reaction Steps

Sequentially treat the product of Step 3 (5.9 g) in CH2Cl2 (80 mL) at 0° C. with N-methyl-N-[2-(methoxyphenyl)methyl]amine (3.8 g), Et3N (3.5 mL) and DMAP (278 mg). Stir the mixture at 0° C. for 2 h, allow to warm to room temperature and stir for 20 h. Wash the reaction mixture with 1N HCl (1×100 mL) and brine (1×100 mL), dry the organic layers over MgSO4, filter and concentrate to afford 3,4-dichloro-β-[2-[[(2-methoxy-phenyl)methyl]-methylamino]-2-oxoethyl] benzenepropanoic acid (9.3 g).

Provenance & Evidence