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HRID22950

反应详情

EQUATION

反应方程式

HRID 22950 的结构方程式

REACTANTS

反应物

1
结构：O=C(N[C@H]1CC[C@H](C(=O)N2Cc3ccc(CO)cc3C2)CC1)OCc1ccccc1
HCID178523771

未命名化合物

PRODUCTS

生成物

1
结构：O=Cc1ccc2c(c1)CN(C(=O)[C@H]1CC[C@H](NC(=O)OCc3ccccc3)CC1)C2
HCID178519307

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Mn+4].[O-2].[O-2]
催化剂HCID178418406

未命名化合物

结构：ClC(Cl)Cl
溶剂HCID6212

Chloroform

CHCl3

PROCEDURE

实验过程

20 g of manganese dioxide was added to 120 ml of a chloroform solution containing 4.0 g of N-benzyloxycarbonyl-trans-4-[(5-hydroxymethyl-2-isoindolinyl)carbonyl]cyclohexylamine, and the mixture was stirred at room temperature for 4 hours. Manganese dioxide was removed by filtration through Celite and the solvent was removed under reduced pressure. The residue was suspended in hexane-ethyl acetate and the crystals were collected by filtration to obtain N-benzyloxycarbonyl-trans-4-[(5-formyl-2-isoindolinyl)carbonyl]cyclohexylamine.

WORKUP

后处理

  1. customManganese dioxide was removed by filtration through Celite
  2. customthe solvent was removed under reduced pressure
  3. filtrationthe crystals were collected by filtration