1-Hydroxybenzotriazole → HCID 178422957, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4-hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid (3.06 g), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (3.17 g), and N-hydroxybenzotriazole (2.53 g) in N,N-dimethylformamide (45 ml) was stirred at 0° C. for 15 minutes. (2E,4E)- and (2Z,4E)-4-Methyl-2,4-heptadien-1-ylamine (2.35 g) was added to the solution. The solution was stirred at 0° C. for 2 hours and then at room temperature overnight. The reaction mixture was diluted with water. The resulting precipitate was filtered and washed with water to give N-[(2E,4E)- and (2Z,4E)-4-methyl-2,4-heptadien-1-yl]-4-hydroxy-7-methyl-1,8-naphthyridine-3-carboxamide (3.5 g).

Provenance & Evidence