反应详情

A mixture of N-(1-tert-butoxycarbonyl-4-methyl-5-benzimidazolyl)-N'-2-aminoethylthiourea (2.89 g) and mercuric acetate (3.32 g) in methanol (200 mL)/chloroform (100 mL) is stirred at room temperature for 2 hours. The resulting black mixture is filtered on Celite and the filtrate rotary evaporated. The residue is purified by flash chromatography on a short pad of silica gel, eluting with 10% methanol/chloroform containing 1% ammonium hydroxide. The product-containing fractions are collected and rotary evaporated to afford 1-tert-butoxycarbonyl-4-methyl-5-(2-imidazolinylamino)benzimidazole as a white solid.

1. filtrationThe resulting black mixture is filtered on Celite
2. customThe residue is purified by flash chromatography on a short pad of silica gel
3. washeluting with 10% methanol/chloroform containing 1% ammonium hydroxide
4. customThe product-containing fractions are collected
5. customrotary evaporated