反应详情

To a solution (50 mL) of tert-butyl 1-(1-amino-1-cyanoethyl)-1-cyclopropanecarboxylate (1.12 g, 5.30 mmol) in ethanol was added a suspension (30 mL) of Raney nickel catalyst (R-100 manufactured by Nikko Rica Corporation, 10 mL) in ethanol, and the suspension was vigorously stirred at room temperature for 6 hours in hydrogen gas atmosphere. The catalyst was removed by filtration through celite, and the solvent was removed by distillation under reduced pressure to obtain 0.84 g (3.92 mmol, 74%) of the crude target compound as a colorless transparent oil. The thus obtained crude product was used in the subsequent reaction with no further purification.

1. customThe catalyst was removed by filtration through celite
2. customthe solvent was removed by distillation under reduced pressure
3. customto obtain 0.84 g (3.92 mmol, 74%) of the crude target compound as a colorless transparent oil
4. customThe thus obtained crude product
5. customwas used in the subsequent reaction with no further purification