Ammonium Chloride → HCID 67686974, compound

Participants

Reaction Steps

Combine 4-(4-chlorobutoxy)benzophenone (8.1 kg, 13.47 mol) and tetrahydrofuran (60 L). Add a solution of benzylmagnesium chloride (21 L, 1.67M in tetrahydrofuran, 35 mol) over about 2.5 hours. After 2 hours, cautiously add aqueous saturated ammonium chloride solution (9 L) over about 1 hour and a precipitate forms. Filter the reaction mixture, rinse with tetrahydrofuran, and extract the filtrate with aqueous saturated sodium chloride solution. Evaporate the separated organic layer in vacuo to give 1-(4-chlorobutoxy)phenyl-1,2-diphenyl ethanol.

Provenance & Evidence