Sodium Hydroxide → HCID 21469826, compound

Participants

Reaction Steps

Combine 4-benzyloxy-4'-hydroxybenzophenone (9.12 g, 30.0 mmol) and sodium hydroxide (1.8 g, 45 mmol) in water (35 mL). Add tetrabutylammonium hydrogensulfate (1.02 g, 3.0 mmol). Add 1-bromo-4-chlorobutane (5.2 mL, 45 mmol). Heat to reflux. After 3 hours, cool the reaction mixture to give a solid. Collect the solid by filtration, rinse with water, and dry to give 4-benzyloxy-4'-(4-chlorobutyloxy)benzophenone: Rf =0.32 (silica gel, 30% ethyl acetate/hexane).

Provenance & Evidence