HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 6-(Morpholine-4-carbonyl)nicotinic acid, t-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 2,5-Pyridinedicarboxylic acid, 2-methyl ester | HCID 42556131 | — |
| Product | 6-(Morpholine-4-carbonyl)nicotinic acid, t-butyl ester | HCID 10085718 | — |
Reaction Steps
In step B, the 2,5-pyridinedicarboxylic acid, 2-methyl ester, 5-t-butyl ester (5) is amidated with morpholine to give the corresponding 6-(morpholine-4-carbonyl)nicotinic acid, t-butyl ester (6).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05691368 |
| Source dataset | uspto-grants-1997_11 |
| ORD ID | ord-bc4c2961429c432ebd2436b8c2d9211e |
| Source note | uspto-grants-1997_11 |