Methanol → HCID 13269697, compound

Participants

Reaction Steps

A quantity of 2.3 gm (0.005 mol) of 5,11-dihydro-11-[(4-pyridinyl)-carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one methoiodide was suspended in 200 ml of methanol, and at 0° C. 0.25 gm (0.006 mol) of sodium borohydride were added thereto in portions. The resulting mixture was stirred for a further hour in an ice bath. Then, the mixture was stirred into 1 liter of ice-cold water and extracted exhaustively with methylene chloride. The combined extracts were washed with water, dried over sodium sulphate, and concentrated by evaporation in vacuo. After being recrystallized from diisopropyl ether/methanol, the colorless crystals melted at 226°-227° C.

Provenance & Evidence