Sodium Bicarbonate → HCID 23696420, compound

Participants

Reaction Steps

A solution of benzyl 6-(1-hydroxyethyl)-3-morpholino-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate (30 mg) in dioxane (3 ml) is diluted with water (1 ml) containing sodium bicarbonate (7 mg). 10% palladium on powdered charcoal (30 mg) is also dried and the resulting mixture is hydrogenated at 40 psi for 30 mins. The catalyst is filtered off and washed with water (3×3 ml). The combined filtrate is extracted with ethyl acetate (3×2 ml), concentrated in vacuo to ca. 2 ml, and lyophilized to give sodium 6-(1-hydroxyethyl)-3-morpholino-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate.

Provenance & Evidence