Hydrochloric Acid → HCID 131713354, compound

Participants

Reaction Steps

In a variation, 40 ml of 3.5 N ethanolic hydrochloric acid were added under an inert atmosphere to a solution of 2.7 g of the product of Step A in 10 ml of ethanol and the mixture was stirred for 8 hours and was then evaporated to dryness. The residue was taken up in ethyl acetate and the solution was iced and vacuum filtered. The product was washed with ethyl acetate, was dried at 60° C. under reduced pressure and was crystallized from methanol to obtain 2.2 g of (2S) 2-amino-N-[(20S)-5α-pregnan-20-ol-3α-yl]-propanamide hydrochloride melting at ≃220° C.

Provenance & Evidence