HCID 68861173, compound → HCID 57758710, compound

HRID 229533Notes

Reaction equation

HRID 229533 reaction equation
C(OC([N:11]1[CH2:15][CH:14]([O:16][CH3:17])[C:13]([NH:19][C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])([CH3:18])[CH2:12]1)=O)C1C=CC=CC=1>CO.[C].[Pd].[H][H]>[C:23]([O:22][C:20]([NH:19][C:13]1([CH3:18])[CH:14]([O:16][CH3:17])[CH2:15][NH:11][CH2:12]1)=[O:21])([CH3:26])([CH3:25])[CH3:24]

Participants

5

Reactant 1

HCID 68861173HCID 68861173, compound

Product 1

HCID 57758710HCID 57758710, compound

Reagents, catalysts & solvents 3

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolventHCID 178418361HCID 178418361, compoundSolvent

Procedure

To a solution of 1-benzyloxycarbonyl-3-(tert-butoxycarbonylamino) 4-methoxy-3-methylpyrrolidine (fraction α) (0.29 g, 0.8 mmol) in methanol (10 mL), 5% palladium-carbon catalyst (water content, 50%; 0.15 g) was added, and the suspension was stirred at room temperature for 16.5 hours in hydrogen atmosphere. The reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure to obtain the title compound as a colorless oily product. This product was used in the subsequent reaction with no further purification.

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-4e44803202d040899cebb244b72b03ef
Source dataset
uspto-grants-2009_07
Patent number
US07563805B2

Reaction notes

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