HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylformanilide → 3,5-Difluorobenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylformanilide | HCID 66737 | — |
| Reactant | HCID 178505930 | HCID 178505930 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3,5-Difluorobenzaldehyde | HCID 588160 | — |
Reaction Steps
The 3,5-difluorobenzaledehyde used as a starting compound can be prepared as follows: 3,5-difluorophenylmagnesiumbromide can be prepared as described by A. Roe and W. F. Little: J.Org.Chem. 20 (1955) 1577. A solution of 3,5-difluorophenylmagnesiumbromide in diethylether is added dropwise to a solution of N-methylformanilide in tetrahydrofuran. By working up this reaction mixture, 3,5-difluorobenzaldehyde is obtained. b55 =86°-88° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04424229 |
| Source dataset | uspto-grants-1984_01 |
| ORD ID | ord-d53c732bdfb34d8180e803f26615771d |
| Source note | uspto-grants-1984_01 |