Nicotinoyl chloride → HCID 136466546, compound

HRID 2295355Notes

Reaction equation

Cl.[OH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:10][NH:11][C:12]3[CH:18]=[CH:17][N:16]=[CH:15][C:13]=3[N:14]=2)=[CH:5][CH:4]=1.[N:19]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([Cl:27])=[O:26])[CH:20]=1>>[ClH:27].[C:25]([N:11]1[C:12]2[CH:18]=[CH:17][N:16]=[CH:15][C:13]=2[N:14]=[C:9]([C:6]2[CH:7]=[CH:8][C:3]([OH:2])=[CH:4][CH:5]=2)[NH:10]1)(=[O:26])[C:21]1[CH:22]=[CH:23][CH:24]=[N:19][CH:20]=1

Participants

Reactant 2

HCID 82604Nicotinoyl chloride

HCID 136423293HCID 136423293, compound

Product 1

HCID 136466546HCID 136466546, compoundYield 79%

Procedure

2.75 g (0.01 moles) of 3-(p-hydroxyphenyl)-1,2-dihydropyrido[3,4-e]-as-triazine hydrochloride are reacted with pyridine-3-carbonyl chloride as described in Example 2 to obtain 1-nicotinoyl-3-(p-hydroxyphenyl)-1,2-dihydropyrido[3,4-e]-as-triazine hydrochloride with a yield of 79%; m.p.: 212°-213° C.

Sources & evidence

ORD record: ord-e6633ee9eb5143269b4eded6d7a0cf64
Source dataset: uspto-grants-1984_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04424351

Reaction notes

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