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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2295358Generated: October 30, 2026

2-Amino-6-benzoyl-1-((isopropyl)sulphonyl)-1H-benzimidazole → 1-Isopropylsulfonyl-2-amino-6-(1-phenyl-1-hydroxy-1-propyl)benzimidazole

https://huagongshe.com/reaction/2295358

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Amino-6-benzoyl-1-((isopropyl)sulphonyl)-1H-benzimidazoleHCID 3017389—
ReactantCarbonyl benzimidazoleHCID 22387228—
ReactantHCID 178506846HCID 178506846—
SolventMethanolHCID 887—
Product1-Isopropylsulfonyl-2-amino-6-(1-phenyl-1-hydroxy-1-propyl)benzimidazoleHCID 20475375—

Reaction Steps

Specifically the carbonyl benzimidazole, 1-isopropylsulfonyl-2-amino-6-benzoylbenzimidazole, is reacted with ethyl lithium to form the desired carbinol, 1-isopropylsulfonyl-2-amino-6-(1-phenyl-1-hydroxy-1-propyl)benzimidazole.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04424362
Source datasetuspto-grants-1984_01
ORD IDord-30ef0c672492401ab237e6c15510d37b
Source noteuspto-grants-1984_01