2-Chloro-4-nitrobenzoic acid → Benzoyl chloride, 2-chloro-4-nitro-

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Reaction Steps

In accordance with Method II, thionyl chloride (800 g, 6.72 m) was added to 2-chloro-4-nitrobenzoic acid (500 g, 2.48 m) while the reaction mixture was warmed. After addition, the mixture was refluxed for approximately three hours. The excess thionyl chloride was removed by distillation and the remaining reaction mixture was vacuum-distilled to yield 2-chloro-4-nitrobenzoyl chloride (510 g, 93% bp 143° C./4 mm).

Provenance & Evidence