HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2295408Generated: October 30, 2026
L-Valine → 2-(4-Trifluoromethylphenylamino)-3-methylbutanoic acid
https://huagongshe.com/reaction/2295408
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | L-Valine | HCID 6287 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Sulfolane | HCID 31347 | — |
| Reactant | Benzene, 1-fluoro-4-(trifluoromethyl)- | HCID 67873 | — |
| Catalyst | Tetrabutylammonium Iodide | HCID 67553 | — |
| Product | 2-(4-Trifluoromethylphenylamino)-3-methylbutanoic acid | HCID 13388453 | 53% |
Reaction Steps
A mixture of 80 parts of p-fluorobenzotrifluoride, 114 parts of valine, 135 parts of potassium carbonate, 65 parts of tetra(n-butyl)ammonium iodide, and 630 parts of sulfolane was placed in a pressure reactor. The reactor was degassed, placed under an argon atmosphere, sealed, and then heated and maintained at about 140° C. for about 18 hours. Analysis of the reaction product indicated 53.0% yield of 2-(4-trifluoromethylphenylamino)-3-methylbutanoic acid, based on p-fluorobenzotrifluoride starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04424396 |
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| Source dataset | uspto-grants-1984_01 |
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| ORD ID | ord-bbc2ddb48bb048ce8e565eef2fd06c81 |
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| Source note | uspto-grants-1984_01 |
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