2-Pyrimidinamine, 4-chloro-6-methoxy- → N-[2-(1,2-Dichlorovinyloxy)phenylsulfonyl]-N'-(4-chloro-6-methoxy-pyrimidin-2-yl)urea

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Reaction Steps

7.4 g of 2-(1,2-dichlorovinyloxy)phenylsulfonylisocyanate and 4.0 g of 2-amino-4-chloro-6-methoxypyrimidine are heated to 70°-80° C. in 60 ml of absolute dioxane for 3 hours. After cooling the mixture is treated with activated carbon, filtered and evaporated to 1/5 of the original volume. From the residue crystallise 9.0 g of N-[2-(1,2-Dichlorovinyloxy)phenylsulfonyl]-N'-(4-chloro-6-methoxy-pyrimidin-2-yl)urea, m.p. 196°-198° C.

Provenance & Evidence