HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2295481Generated: October 29, 2026
Methanol → 6-(4'-Chloro-phenyl)-6-oxo-4-chloro-3,3-dimethyl-hexanoic acid methyl ester
https://huagongshe.com/reaction/2295481
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3,3-Dimethyl-4-(4'-chloro-phenacyl)-gamma-butyrolactone | HCID 20474509 | — |
| Product | 6-(4'-Chloro-phenyl)-6-oxo-4-chloro-3,3-dimethyl-hexanoic acid methyl ester | HCID 54116059 | — |
Reaction Steps
134 g of 3,3-dimethyl-4-(4'-chloro-phenacyl)-γ-butyrolactone were dissolved in 215 g of thionyl chloride in a 0.7 liter autoclave with a glass liner. 100 g of methanol were then pumped in and the mixture was heated to 50° C. for 4 hours. After working up as in Example 10, 6-(4'-chloro-phenyl)-6-oxo-4-chloro-3,3-dimethyl-hexanoic acid methyl ester was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04425282 |
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| Source dataset | uspto-grants-1984_01 |
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| ORD ID | ord-1de28fd63cad4bea9b15e7d13b28bc1c |
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| Source note | uspto-grants-1984_01 |
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