Ammonia → α-Phenyl-2-benzothiazolemethanamine

HRID 2295486Notes

Reaction equation

HRID 2295486 reaction equation
Cl.[NH2:2][CH:3]([C:10]1[S:11][C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.N>C(Cl)Cl>[NH2:2][CH:3]([C:10]1[S:11][C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 23318519HCID 23318519, compound

Product 1

HCID 13342005α-Phenyl-2-benzothiazolemethanamine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The hydrochloride was dissolved with aqueous ammonia and methylene chloride, the aqueous layer was extracted with two portions of methylene chloride. The combined methylene chloride extracts were washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. 13.1 g. of white solid of desired producted was obtained, mp. 68°-70° C.

Workup

  1. extractionthe aqueous layer was extracted with two portions of methylene chloride
  2. washThe combined methylene chloride extracts were washed with brine
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo
  6. customof white solid of desired producted was obtained

Sources & evidence

ORD record
ord-437c62e85e7d49d09e9685a0b2096388
Source dataset
uspto-grants-1984_01
Patent number
US04425338

Reaction notes

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