1-Phenylpiperazine → HCID 70504599, compound

Participants

Reaction Steps

To a solution of 4.87 g of N-phenylpiperazine in 150 ml of dichloromethane containing 4.59 ml of triethylamine is added dropwise with stirring under nitrogen a solution of 4.82 g of benzenesulfinyl chloride in 50 ml of dichloromethane. The reaction mixture is stirred for 3 hours at room temperature, diluted with 100 ml of dichloromethane and washed with 150 ml of water and 100 ml of 5% potassium carbonate solution. The organic layer is dried over anhydrous sodium sulfate and evaporated in vacuo to a nearly colorless crystalline solid. Recrystallization from ethanol affords 6.37 g of 1-phenylpiperazine-4-benzenesulfinamide as a nearly colorless crystalline solid, mp, 101°-104° (softens 98°).

Provenance & Evidence