Triethylamine → HCID 70505000, compound

Participants

Reaction Steps

To a solution of 4.90 g of 1-(2-pyridyl)piperazine in 150 ml of dichloromethane containing 4.59 ml of triethylamine is added dropwise with stirring under nitrogen a solution of 4.82 g of benzenesulfinyl chloride in 50 ml of dichloromethane. The reaction mixture is stirred for 3 hours at room temperature, diluted with 100 ml of dichloromethane, and washed with 150 ml water and 100 ml 5% potassium carbonate. The organic layer is dried over sodium sulfate and evaporated in vacuo to give a yellow crystalline solid. Recrystallization from ethanol affords 4.14 g of 1-(2-pyridyl)piperazine-4-benzenesulfinamide as a colorless crystalline solid, mp 83°-86° (soften 81°). A second crop (1.24 g) is obtained by concentration of the mother liquors, total yield: 5.38 g.

Provenance & Evidence