Acetic Anhydride → HCID 15587184, compound

HRID 2295494Notes

Reaction equation

HRID 2295494 reaction equation
[OH:1][CH2:2][CH2:3][S:4][CH:5]([C:8]1[C:17]2[C:12](=[CH:13][C:14]([O:20][CH3:21])=[C:15]([O:18][CH3:19])[CH:16]=2)[CH2:11][CH2:10][N:9]=1)[C:6]#[N:7].[C:22](OC(=O)C)(=[O:24])[CH3:23]>C1C=CC=CC=1>[C:22]([O:1][CH2:2][CH2:3][S:4][CH:5]([C:8]1[C:17]2[C:12](=[CH:13][C:14]([O:20][CH3:21])=[C:15]([O:18][CH3:19])[CH:16]=2)[CH2:11][CH2:10][N:9]=1)[C:6]#[N:7])(=[O:24])[CH3:23]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 15587168HCID 15587168, compound

Product 1

HCID 15587184HCID 15587184, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To 1.0 g. of α-(2-hydroxyethylmercapto)-6,7-dimethoxy-3,4-dihydro-1-isoquinolyl-acetonitrile 5 ml. of acetic anhydride and 15 ml. of benzene are added and the reaction mixture is refluxed for 4 hours. The mixture is then evaporated to dryness and to the residue carbon tetrachloride is added. 0.6 g. of α-(2-acetoxyethyl-mercapto)-6,7-dimethoxy-3,4-dihydro-1-isoquinolyl-acetonitrile are obtained, melting at 157° C. after recrystallization from butanol.

Workup

  1. temperaturethe reaction mixture is refluxed for 4 hours
  2. customThe mixture is then evaporated to dryness and to the residue carbon tetrachloride
  3. additionis added

Sources & evidence

ORD record
ord-8a5b857e22884ec58096ee578edc69c6
Source dataset
uspto-grants-1984_01
Patent number
US04425349

Reaction notes

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