HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 13316885, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Isobutyl chloroformate | HCID 62365 | — |
| Reactant | L-Proline | HCID 145742 | — |
| Reactant | HCID 13316857 | HCID 13316857 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 13316885 | HCID 13316885 | 68% |
Reaction Steps
The suspension of mixed anhydride in THF is prepared by using 1.78 g of (2R,4R)-3-(S-acetyl-3-mercaptopropanoyl)-2-(2-hydroxyphenyl)-4-thiazolidinecarboxylic acid, 0.51 g of N-methylmorpholine and 0.68 g of isobutyl chlorocarbonate. To the suspension the solution of 1.0 g of L-proline and 1.0 g of triethylamine dissolved in aqueous THF is added, and treated in the same manner as Example 1 to give 1.5 g (68%) of the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04425333 |
| Source dataset | uspto-grants-1984_01 |
| ORD ID | ord-8f5123c3f0054d77a6642392c0d71a67 |
| Source note | uspto-grants-1984_01 |