反应详情

100 gm of 1-methylcyclopropanoic acid was added to 150 ml of diethyl ether. The system was cooled to 0°-5° C. and 119 gm of thionyl chloride was added dropwise over a period of time. After addition, the system was heated at reflux for 8 hours. The system was then cooled to 0°-5° C. and 62 gm of ethanethiol was added dropwise. The system was heated at reflux for 6 hours and then stirred at room temperature for 72 hours. The diethyl ether was removed by stripping to give the 1-methylcyclopropanoic acid ethyl ester.

1. temperatureThe system was cooled to 0°-5° C.
2. additionAfter addition
3. temperaturethe system was heated
4. temperatureat reflux for 8 hours
5. temperatureThe system was then cooled to 0°-5° C.
6. temperatureThe system was heated
7. temperatureat reflux for 6 hours
8. customThe diethyl ether was removed