Acetic Acid → HCID 13116412, compound

Participants

Reaction Steps

Ethyl 6,7-dichloro-5-oxo-1,2-dihydro-5H-thiazolo[3,2-a]quinoline-4-carboxylate (1.0 gram, 2.9 mmol) obtained in Example 3 was suspended in a mixture of 2.0 grams of sodium hydroxide, 140 ml of ethanol and 60 ml of water, the mixture was heated to reflux for thirty minutes, acidified with acetic acid when it was still hot, crystals separated out were collected by filtration, washed with water, and dried and recrystallized from dimethyl formamide to give 580 mg (62.8 percent) of the title compound. Melting point 305° to 310° C. (decomposition). Elementary analysis calculated as C12H7Cl2NO3S: C 45.59, H 2.23, N 4.43; Found: C 45.85, H 2.19, N 4.37.

Provenance & Evidence