Piperazine → HCID 13116413, compound

Participants

Reaction Steps

A mixture of 500 mg (1.58 mmol) of 6,7-dichloro-5-oxo-1,2-dihydro-5H-thiazolo(3,2-a)quinoline-4-carboxylic acid, 1.0 gram (11.6 mmol) of piperazine, and 20 ml of pyridine was heated to reflux for ten hours. The content was then concentrated under reduced pressure, water was added to the residue, insoluble matters were taken out by filtration, washed with water, dried, and recrystallized from dimethyl formamide to give the title compound. Yield was 420 mg (72.7 percent). Melting point: 244° to 245° C. (decomposition). Elementary analysis calculated as C16H16ClN3O3S.21/2 H2O: C 46.77, H 5.15, N 10.22; Found: C 46.66, H 4.90, N 9.81.

Provenance & Evidence