Pyridine → HCID 13116432, compound

Participants

Reaction Steps

A mixture of 500 mg (1.67 mmol) of 8-chloro-7-fluoro-5-oxo-1,2-dihydro-5H-thiazolo(3,2-a)-quinoline-4-carboxylic acid and 1.09 grams (8.34 mmol) of N-(beta-hydroxyethyl)-piperidine was suspended in 20 ml of pyridine and the mixture was heated to reflux for thirty two hours. When the reaction was completed, the mixture was cooled to a room temperature, crystals separated out therefrom were collected by filtration, successively washed with pyridine, ethanol and ether, and recrystallized from dimethyl formamide to give the title compound as pale yellow powders. Yield 426.6 mg (65 percent). Melting point 256° to 256.5° C. Elementary analysis calculated as C18H20FN3O4S: C 54.95, H 5.12, N 10.68; Found: C 54.52, H 5.14, N 10.73.

Provenance & Evidence