Tetrahydrofuran → HCID 53718407, Verbindung

HRID 2295735Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2295735
O1CCCC1.Cl.[NH2:7][C:8]1[C:17]2[C:12](=[CH:13][C:14]([O:20][CH3:21])=[C:15]([O:18][CH3:19])[CH:16]=2)[N:11]=[C:10]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[N:9]=1.[CH3:28][C:29](=[CH:33][CH3:34])[C:30](Cl)=[O:31]>C(N(CC)CC)C>[NH2:7][C:8]1[C:17]2[C:12](=[CH:13][C:14]([O:20][CH3:21])=[C:15]([O:18][CH3:19])[CH:16]=2)[N:11]=[C:10]([N:22]2[CH2:27][CH2:26][N:25]([C:30](=[O:31])[C:29]([CH3:28])=[CH:33][CH3:34])[CH2:24][CH2:23]2)[N:9]=1

Komponenten

5

Edukt 3

HCID 8028TetrahydrofuranHCID 3015793HCID 3015793, VerbindungHCID 204738332-Piperazine-4-amino-6,7-dimethoxyquinazoline hydrochloride

Produkt 1

HCID 53718407HCID 53718407, VerbindungAusbeute 47,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

To 20 ml of tetrahydrofuran were added 2.4 g of 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline hydrochloride and 2.6 g of triethylamine, after which the mixture was stirred for 20 minutes. There was then added 0.7 g of 2,3-dimethylacryloyl chloride, after which the mixture was stirred at room temperature for 12 hours. The crystals which were produced were collected by filtration, washed with water and recrystallized from ethanol, to give 1.04 g of the desired Compound No. 3 in the form of pale yellow prisms melting at 219.5°-221.5° C.

Aufarbeitung

  1. stirringafter which the mixture was stirred at room temperature for 12 hours
  2. customThe crystals which were produced
  3. filtrationwere collected by filtration
  4. washwashed with water
  5. customrecrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-69487d0f1ece4a14be25c892c599fac4
Quelldatensatz
uspto-grants-1984_01
Patentnummer
US04426382

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