2-Chloro-6,7-dimethoxy-4-quinazolinamine → HCID 20473825, compound

Participants

Reaction Steps

To 24 ml of isopentanol were added 1.2 g of 4-amino-2-chloro-6,7-dimethoxyquinazoline and 1.35 g of 1-(phenylcyclopropylcarbonyl)piperazine. The resulting mixture was heated under reflux for 4 hours and then the crystals thereby produced were collected by filtration and recrystallized from a 50% v/v aqueous ethanol, to give 1.74 g of the desired Compound No. 33 hydrochloride hydrate in the form of colourless prisms melting at 287°-288° C. (with decomposition).

Provenance & Evidence