2-Chloro-6,7-dimethoxy-4-quinazolinamine → HCID 20473858, compound

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Reaction Steps

To 25 ml of isopentanol were added 1.0 g of 4-amino-2-chloro-6,7-dimethoxyquinazoline and 1.37 g of 1-(1-phenylcyclohexylcarbonyl)piperazine, and the resulting mixture was heated under reflux for 4 hours. The crystals thereby produced were collected by filtration and neutralized by the addition of a 10% w/w aqueous solution of sodium hydroxide. The resulting mixture was extracted with chloroform and the extract was subjected to silica gel chromatography and eluted with chloroform. A 10% w/w solution of hydrogen chloride in ethanol was added to the eluate and the crystals thus produced were collected by filtration, to give 0.93 g of the desired Compound No. 63 hydrochloride hydrate in the form of pale yellow powdery crystals melting at 278°-279° C. (with decomposition).

Provenance & Evidence