2-Chloro-6,7-dimethoxy-4-quinazolinamine → HCID 70510252, compound

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Reaction Steps

To 25 ml of isopentanol were added 1.2 g of 4-amino-2-chloro-6,7-dimethoxyquinazoline and 1.4 g of 1-(trans-2-phenylcyclopropylcarbonyl)piperazine, and the resulting mixture was heated under reflux for 4 hours. The crystals thus produced were collected by filtration and neutralized by the addition of a 20% w/w aqueous solution of sodium hydroxide. The resulting mixture was extracted with chloroform and the extract was charged into a silica gel chromatography column and eluted with chloroform. A 10% w/w solution of hydrogen chloride in ethanol was added to the eluate and the crystals thus produced were collected by filtration, giving 1.22 g of the desired Compound No. 34 hydrochloride dihydrate in the form of colourless powdery crystals melting at 195°-198° C. (with decomposition).

Provenance & Evidence